| New Data Confirms That A Selective, Fully Human Anti-VEGF Antibody ...
Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) a clinical stage biopharmaceutical company developing targeted monoclonal antibodies for the treatment of cancer and hepatitis C virus (HCV) infection, reported that preclinical data presented at IBC's 5th Annual International Anti-Angiogenesis Conference showed that its anti-VEGF antibody R84 was as effective as Avastin(R) (bevacizumab) in inhibiting tumor growth in a mouse model of human breast cancer. R84 is a selective, fully human monoclonal antibody that blocks the cancer-promoting agent vascular endothelial growth factor (VEGF). R84 selectively blocks VEGF from binding only to VEGF receptor 2 (VEGFR2), while non-selective agents such as Avastin block binding to both VEGFR2 and VEGF receptor 1 (VEGFR1). Selective anti-VEGF agents may have potential advantages over non-selective approaches and Peregrine is now assessing R84 as a candidate for clinical development.
Obesity May Worsen Ovarian Cancer
The doctors included James Pavelka, MD, and Andrew Li, MD, of Cedars-Sinai Medical Center in Los Angeles. If their finding is correct, it could lengthen the list of possible links between obesity and cancer. Obesity has already been tied to cancers of the breast, colon, esophagus, kidney, and endometrium (inner uterus lining). Links to ovarian cancer haven't been certain, the researchers note. They studied the records of 216 women undergoing surgery and treatment for ovarian cancer at Cedars-Sinai Medical Center. The patients were in their late-50s to mid-60s, on average. They included 146 women with advanced ovarian cancer (stage III or IV ovarian cancer). Ovarian cancer is hard to spot in its earliest, most treatable stages.
Shop with the wife? Sit around? I’ll take the stage
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New Computational Technique Can Predict Drug Side Effects
Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process. Now researchers at the University of California, San Diego (UCSD) have developed a novel technique using computer modeling to identify potential side effects of pharmaceuticals, and have used the technique to study a class of drugs that includes tamoxifen, the most prescribed drug in the treatment of breast cancer. Their study is currently available on line at PLoS Computational Biology.
Conventional test methods screen compounds in animal studies in advance of human trials in the hope of identifying the side effects of promising therapeutics. The UCSD team - led by Philip Bourne, Ph.D., professor of pharmacology at UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences and Lei Xie, Ph.D., of the San Diego Supercomputer Center at UCSD - instead uses the power of computational modeling to screen specific drug molecules using a worldwide repository, the Protein Data Bank (PDB), containing tens of thousands of three-dimensional protein structures.
CALDWELL'S WWE SURVIVOR SERIES REPORT 11/18: Ongoing "virtual time ...
Back in the ring, Mickie gave Melina the kiss of death before attempting a spin kick to the head that caught more air than face. She made the cover for the win. WINNERS: Mickie's team in 5:00. It was what it was. Too much of the unexperienced divas for my taste, but they continue to build up Mickie as an eventual challenger to Beth. Something ain't right with Melina. (1/2*) Backstage, Coach and William Regal exchanged grins while Hornswoggle paced the Raw GM office. Ross talked about Hornswoggle vs. Khali tonight. They went to footage from promos earlier in the day. Randy Orton said the fans are going to be disappointed because he's going to beat Shawn Michaels tonight. He said Michaels's only chance at survival was the superkick, which was taken away. Orton said Michaels will be broken tonight.
Canada slips in gender equality
A woman still has to work much harder and smarter than a man in any corporate setting if she wants to get ahead. Even then, she'll most likely be excluded from the top ranks, just because she's a woman.
Music orchestra? Same thing. Until certain orchestras started doing blind auditions, they were 90% men, and woman only had minor roles. When they started doing blind auditions, women were suddenly winning first-trumpet and first-violin positions in the orchestra. That is 100% proof that there was discrimination.
Unfortunately, at the corporate level they still don't do blind interviews and auditions for senior positions. Until then, woman will continue to be excluded.
So to answer your question: men aren't counted because men still form the dominant group.
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